Meredith Grey, Grey's Anatomy

Meredith was abandoned by her father as a child, ignored by her mother who then developed Alzheimer’s and died from it, adopted a dog who died shortly after, fell in love with a man only to find out that he was both her boss and married to another woman, eventually married that man after his divorce but suffered miscarriages and adoption issues, and later witnessed her husband’s death after a car accident. Also, her best friend moved away, many of her co-workers died in horrific accidents, she briefly “died” herself during a ferry boat accident and she was in a plane crash. She might have even worse luck than Kenny. 

Image: Grey's Anatomy Wiki